KINE 2011 Lecture Notes - Lecture 20: V(D)J Recombination, B-Cell Receptor, Innate Immune System
17 Sep 2017
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Two classes of adaptive immunity: antibody (dissolved proteins, they were one of your plasma proteins) mediated (humoral): production of antibodies by plasma cells which differentiate from b lymphocytes. Dissolved proteins in the fluid parts of your body: cell mediated: activated t lymphocytes. T cells always need cell contact to be activated. The antibodies do the work of your immune response. *b and t cell development occurring in bone marrow during most of your life. When you"re a fetus, a lot of blood cell development occurs in the liver, but shortly after your born your stem cells reside in the bone marrow. For your b cells, most of your development occurs in this. T cells by the time they leave the thymus are mature. Once they are in circulation, they circuit between the blood circulation and the blood tissues. Each b lymphocyte has surface receptor for one antigen (antigen specific) b cell receptor or surface/membrane immunoglobulin.
