KINE 2031 Lecture Notes - Lecture 18: Lightdark, Master Clock, Growth Hormone Deficiency
2 Jul 2018
School
Department
Course
Professor
Hypothalamic Releasing & Inhibiting
Hormone
-Anterior pituitary hormones are not secreted at constant rates
-Secretion regulated by hypothalamic hormones & negative feedback from target-gland
hormones
Role of Hypothalamic Releasing & Inhibiting Hormones
-Hypothalamic hypophysiotropic hormone controls output of anterior-pituitary tropic
-Secretion of each AP hormone is stimulated or inhibited by hypophysiotropic hormones
-Hypothalamic hypophysiotropic anterior pituitary hormone target endocrine glands
hormone
oThyrotropin-releasing hormone (TRH)- stimulates release of TSH & prolactin
oCorticotropin-releasing hormone (CRH) -stimulates release of ACTH
oGonadotropin-releasing hormone (GnRH)- stimulates release of FSH & LH
(gonadotropins)
oGrowth hormone releasing hormone (GHRH) -release of GH
oGrowth hormone inhibiting hormone (GHIH) aka somatostatin – inhibits release
of GH & TSH
oProlactin-releasing hormone (PRH)- stimulates release of prolactin
oProlactin- inhibiting hormone (PIH) – Inhibits release of prolactin
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Document Summary
Anterior pituitary hormones are not secreted at constant rates. Secretion regulated by hypothalamic hormones & negative feedback from target-gland hormones. Hypothalamic hypophysiotropic hormone controls output of anterior-pituitary tropic. Secretion of each ap hormone is stimulated or inhibited by hypophysiotropic hormones. Continuous net protein synthesis occurs under influence of growth hormones as bodily steadily gets larger. Growth requires net synthesis of proteins & includes lengthening of long bonds. Bone is a form of connective tissues, it consists of cells & extracellular organic matrix produced by cells. Bones cells that produce organic matrix are called osteoblasts. Bones are brittle but have high degree of elasticity provided by collagen. Cartilage is like bone, except living cartilage is not calcified. Growth in thickness of bone is achieved by adding new bone on top of outer surface of already existing bone. Osteoblasts activity deposits new bone on externa surface; osteoclasts dissolve the bony tissues on inner surface.
