KINE 2031 Lecture Notes - Lecture 14: Metabolic Acidosis, Muscle Fatigue, Delayed Onset Muscle Soreness
2 Jul 2018
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Creatine Phosphate
-Creatine phosphate contains high energy phosphate group which can be transferred to ADP to form
ATP
-Energy is released when bond b/t phosphate & creatine is broken – catalyzed by creatine kinase
Creatine Phosphate + ADP Creatine + ATP
-A resting muscle contains energy stored as creatine phosphate. On contraction/activity, ATP can be
formed rapidly from creatine phosphate. Creatine phosphate first supplies additional ATP when
exercise begins
Oxidation Phosphorylation
-Oxidative phosphorylation takes place in muscle mitochondria if sufficient oxygen is present.
-Pathways uses breakdown of glucose & fatty acids to generate ATP. 36 ATPs generated/glucose
-Oxidative phosphorylation supplies enough ATP for light exercise; for intense exercise, O2 supplies are
depleted.
-Muscles have myoglobin-stores O2 & increase rate O2 transfer to muscle fibers
-Muscle cells store limited quantities of glucose in form of glycogen
Glycolysis
-If inadequate O2 during intense exercise, muscle fibers rely on increasing glycolysis to generate ATP
-Glycolysis takes place in cytosol of muscle cells – extracts 2 ATPs
-During glycolysis, a glucose molecule broken down to pyruvate to give 2 ATP
-Pyruvate can continue to TCA/ Krebs Cycle where coenzymes NAD & FAD collect hydrogen atoms &
deliver them to ETC to generate ATP
-Advantages Of glycolysis over oxidative phosphorylation:
1. Glycolysis forms ATP anaerobically when insufficient O2
2. Proceeds more rapidly than Oxidative phosphorylation
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Document Summary
Creatine phosphate contains high energy phosphate group which can be transferred to adp to form. Energy is released when bond b/t phosphate & creatine is broken catalyzed by creatine kinase. Creatine phosphate + adp creatine + atp. A resting muscle contains energy stored as creatine phosphate. On contraction/activity, atp can be formed rapidly from creatine phosphate. Creatine phosphate first supplies additional atp when exercise begins. Oxidative phosphorylation takes place in muscle mitochondria if sufficient oxygen is present. Pathways uses breakdown of glucose & fatty acids to generate atp. Oxidative phosphorylation supplies enough atp for light exercise; for intense exercise, o2 supplies are depleted. Muscles have myoglobin-stores o2 & increase rate o2 transfer to muscle fibers. Muscle cells store limited quantities of glucose in form of glycogen. If inadequate o2 during intense exercise, muscle fibers rely on increasing glycolysis to generate atp. Glycolysis takes place in cytosol of muscle cells extracts 2 atps.
