KINE 2475 Lecture Notes - Lecture 8: Iron Overload, Heinz Body, Intestinal Epithelium
13 Jan 2020
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Document Summary
Iron homeostasis, toxicity & treatment of anemia: iron homeostasis (uptake, tf, ferritin, tfr, causes of iron deficiency (anemias, diagnosis of iron deficiency, iron supplementation (drug interactions, iron overload (toxicity & mechanism) Fe is valuable resource for humans, parasites & bacteria. Iron homeostasis, reserves: total body iron content: men 49 mg/kg; women 38 mg/kg, major body reserves: Liver (b/c cyp enzymes which require fe: male/female #"s for breakdown of body iron. Most fe is locked up in hb. There is some myoglobin (muscles) master reserve so we don"t undergo severe hypoxia. Fe iron is toxic (fenton rxn produce oh) Fe needs to be bound to proteins to prevent cellular damage (heintz bodies) Heinz bodies are inclusions in rbcs composed of denatured hb. Chelators are small molecules that bind tightly to metal ions: transferrin: moves fe around body; ferritin: storage. Iron homeostasis, absorption: iron/heme are released from foods by proteolytic digestion in gut.
