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KINE 3012 Lecture Notes - Efferent Arteriole, Inulin, Antibody

Kinesiology & Health Science
Course Code
KINE 3012
Tara Haas

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25 March 25, 13
perritubular but in loop of henle called vaso recta
The Glomerulus
- Bowmans capsule that surrounds the glomerulus
- Afferent brings it into glomerulus
- Glomerulus is essentially looped capillaries -- > eventually blood exits into
efferent arteriole
- Capillary = endothelium
- Tubule = epithelium
Podocytes & the Filtration Barrier
Outside of the basement membrane called a podocyte
- which have a large cell body, “foot processes”
- but don’t have a complete barrier, they have gaps in between
- glomerulus job is to get fluid through the membrane and into the bowman’s
capsule (movement of filtrate)
- Fenestrated means they have a gap in between
- Basement made of mesh proteins
- Gaps between podocytes called “filtration slit”
- Loose ->> more permissive to water and molecules than in the systemic
- Cant pass glomerulus RBCs WBCs Large proteins albumins
immunoglobulins - too large to fit through
- Basement membrane has a lot of negatively charged proteins and plasma
tends to be negatively charged
- Left with small molecules, ions and water
Overall Picture of Plasma Filtration and Fluid Reabsorption
20% leaves the glomerulus leaves to the tubule
80% leaves for peritubular capillary
Inulin to assess your glomerulus filtration / kidney function
Sodium, urea ->> appears in urine in a fration of what was filtered (some is retained
No reabsorption + secretion H+ K+ Penicillin highly secreted as it passes
peritubular capillaries
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