KINE 3670 Lecture Notes - Lecture 12: Tyrosine Hydroxylase, Caudate Nucleus, Mesolimbic Pathway
24 Dec 2015
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Document Summary
Dopamine synthesis is in the catecholamine pathway. Each of the 3 neurotransmitters are produced from a different subset. Starts with tyrosine neutral amino acid derived from phenylalanine. Know this enzyme tyrosine hydroxylase; first rate limiting enzyme. Initial pathway tyrosine l-dopa are found in neurons that produce that starts the reaction dopamine. Expressed in the brain stem in different regions than the norepinephrine. Require the same things that metabotropic receptors need. Drugs lead to upregulation to tyrosine hydroxylase as well (they don"t just affect receptors, they also upregulate gene expression) Striatum is divided into the caudate nucleus and the putamen. Dopamine is typically involved in the homeostasis of these effects but is skewed in drug use. Role depend son which pathway it is going through. Typically takes dopamine back out of the cleft. Mao recycles dopamine; and it gets reproduced in the mitochondria. Most of the pathways described above have gs pathways they stimulate.
