KINE 4370 Lecture Notes - Apoptosis, Brain-Derived Neurotrophic Factor, Neurotrophin
5 Dec 2013
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Document Summary
How neurons generates axons over time axons build end feet highly specialized structure (has a specific class proteins located at the growth cone of the neuron to crawl to its target location). Growth cones are the primary structure that becomes the axon. F-actin and microtubules and other proteins/products are found at the base of the growth cone. The leading edge growth of the growth cone development is driven by intracellular [ca2+] Factors that attract outgrowth process, trophic factors (attracting out growing axon): pioneer growth cone leading edge is determined by trophic factors that repel it or attract it. Netrin/slit family protein on the growth cone and the receptor robo is important for attacting the outgrowth on the other cell. Netrins chemotropically regulate pathway formation the delevping spinal cord midline growth of neuron"s axon guidance to stay at one side of the midline. Non-diffusible signals and diffusible signals these factors are active at a long range.
