KINE 1020 Lecture Notes - Creatine Kinase, Endoplasmic Reticulum, Hypocalcaemia
22 Apr 2014
School
Department
Course
Professor
Document Summary
Description: sensation of discomfort or pain in sm that occurs following unaccustomed movement/activity, an insult to sm that releases its contents into the circulation (rhabdomyosis, muscle proteins are found in the blood. Increases first 24 hrs peaks 24-72 hrs subsides 5-7 days later. Non traumatic increased muscle exertion: heat cramps, conclusions, drugs, genetic conditions inflammation (primary, secondary) Traumatic crash injuries: electric shock, pressure necrosis (cell damage death, arterial occlusion surgery. Signs and symptoms: myalgia, localized pain (site of trauma , muscle weakness and swelling, doughy soft feelings in muscles, edema and discoloration, nausea and fever creatine kinase muscle form (ck-mm) Clinical assessment: myoglobinemia, hypocalcaemia, hypophosphatemia, abnormal histology (necrotic areas, structural damage. Increased protein breakdown (calpain proteases continues, and ros made in mitochondria) Autogenesis stage: some structure inside the mitochondria is lost, swelling of sarcoplasmic reticulum gets bigger. Inflammatory processes: neutrophil accumulation in muscle, monocyte and macrophage accumulation.
