Class Notes (806,520)
Canada (492,274)
York University (33,488)
KINE 2011 (149)
Gillian Wu (25)


5 Pages
Unlock Document

York University
Kinesiology & Health Science
KINE 2011
Gillian Wu

Tubule system = Bowman’s capsule, loop of Henley, (would do nothing w/o vascular system need to have exchange b/w the two system to do process of urine production) Vascular network can be seen in series of diff vessels, Renal artery brings blood into afferent arteriole (leads to individual Glomerulus) Glomerulus is just a cluster of capillaries. Efferent arterioles feed next type Peritubular are the capillaries are the capuillaries wrapped around loop of Henley of the majority of the nephrons, Vesa Recta are referring to the specific capillaries wrapped around loop of Henely (deepest of nephrons) that go down into the medulla . Leads into venules, empty into renal vein to take things away Arterioles= vasoconstriction and vasodilation Capillaries= exchange Kidney= fluid exchange Two major areas exchange b/w (i) Vascular (Glomerlus) (ii) Tubular (Peritbular OR Vesa Recta) ** very important to reclaim that vol which was filtered in glomerulus , things which got filtered will be reabsorbed back into the glomerulus. Diagram on the right is simple illustration of the nephron 1. Kidenys recive 20% of Cardiac Output , Cardiac output 5l/Min .. how much plasma enters the kidney per day 5/L min * 60min/hour * 24 hours /day =7200L/Day (amount of blood heart is pumping in a day at resting cardiac output) -Kidney is 20% 7200* .20 = 1440 L/min ( big portion of blood cannot be filtered , how much of this volume is just plasma) 3L outta the 5L is plasma, that’s 60% so that means 1440 * 0.60 =840 plasma 20% of plasma is filtered 840* 0.20 =168 168 is going to be filtered that crosses from the plasma, and into Bowman space and becomes filtrate. Once plasma crosses out the Glomerulus and into the tubule it is referred to as FILTERATE 20% crosses out of the glomerulus and into the tubule to BECOME FILTERATED. 80% continues its way out to efferent arterioles and into pertubular tubules. Reducing the amount which is filtered, when you have kidney damage, toxicity builds in the blood and could be harmful. If 120ml of plasma are filtered each minute, and the filteration fraction is 20%? What is the daily renal plasma flow? 120ml//min * 60 min/hour * 24 hr/day =172,800ml per day is filtered 172.8 L/day which represents 20% of total renal plasma flow 172.8 / .20 = 864 L /day Three Critical Functions of the nephron: 1. The starting off point (Glomerular filteration process) . Non discriminant filteration means that any plasma components that can fit through filteration slits, is going to move through. Bulk flow process. 20% of everything is going which is right size. That creates filterate and once that filterate is in the tubule, we want to be more selective 2. Tubular Reabsorption: Move substances from the filtrate across the wall of the tubule, across the interstitial fluid and into per tubular capillary 3. Tubular secretion: unique process within the kidney, this is movement of substances from the peritubular capillaries, across interisital fluid , and into the tubular filterate. VERY SELECTIVE—only going to apply to certain molecules subjected to the secretion. Another way kidney adds substance to the filterate. How substance is being handled? Amount filtered – Amount reabsorbed + Amount secreted = Amount of Solute excreted F R S E Not all substances handled equally! 4 examples, looking at particular substances dissolved in plasma (dots ) 1.Filteration: The amount of the substance that was filtered (20%). This is a process that occurs across the board. Similar thing happens in each of the other examples. (Stuff gets filtered but nothing happens not reabsorbed or excreted ) (what u filter = what u will get in urine Example: No Reabsorption
More Less

Related notes for KINE 2011

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.