KINE 4510 Lecture Notes - Myosin Light-Chain Kinase, Hypertrophic Cardiomyopathy, Myosin
25 Mar 2014
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There are two properties of muscle you need to fully understand: the force-length relationship, the dependence of force generation on the intracellular ca2+ levels. Ca2+ acts as a catalyst for activating the atpase in muscle for the purposes of conversion of chemical energy into force. 1. 01. 41. 82. 22. 63. 03. 43. 8020406080100myofilament overlap cardiac muscle(starling)sarcomere length ( m)tension (% max)heavy filament myosin. Myosin is the molecular motor of the contractile protein machinery. It is the protein that converts chemical energy from atp to mechanical energy, thus generating force and movement. There are least 15 different classes of myosin; the myosins involved in force generation and movement in muscle (cardiac, skeletal and smooth muscle are comprised of type ii. Type ii dimerizes two myosin moleculae are connected by coil-coil structures in the tail. Type i is the most primitive myosin: moves molecular cargos . are ca2+-dependent via. Myosins are generally large proteins with a total molecular mass of ~500,000 da.
