NATS 1610 Lecture Notes - Motor Protein, Telophase, Metaphase
21 Jan 2014
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Document Summary
L21 forming the living body mitosis. Three distinct but interconnected events of cell division: duplication of genetic material (dna) Preparation for cell division: dna replicated, sister chromatids. With associated proteins: tightly associated at centromere. Serves as attachment site for kinetochore (proteins) used in sorting chromosomes. Mitotic spindle apparatus (or mitotic spindle) organizes and sorts the chromosomes during mitosis: centrosomes. Single centrosome duplicates at the beginning of m phase: each will define a spindle pole , spindle formed from microtubules. Polymers of tubulin proteins: different sets of microtubules. Kinetochore attached to kinetochore bound to centromeres of each chromosome. Prophase: duplicated chromosomes condense & become visible, nuclear envelope starts to break down, centrosomes move apart & mitotic spindle begins to form. Prometaphase: nuclear membrane gone, bipolar mitotic spindle forms. Cytoplasm cleared in area: chromosomes develop kinetochore at centromere. Attach to kinetochore microtubules (kmt: chromosomes move along spindle.
