NATS 1675 Lecture Notes - Lecture 13: Sister Chromatids, Robert Crippen, Nondisjunction
Document Summary
Nats 1675 lecture #13 chromosomal abnormalities. Many gene reside on the same chromosome so in meiosis, they will travel together. These traits that the particular genes produced link or both occur on the same chromosome. Following mandel"s 3rd principle [principle of independent assortment or recombination], the assortment of the genes on the same chromosome is inter-dependent (so they travel together) not independent. Genes on a different chromosome travel independent of each other. It includes a variety of alterations either in the configuration of chromosomes [deletion or translocation], number of chromosomes or mosaicism. These abnormalities are more extensive than mutations & many are lethal (deadly) Because chromosomal abnormalities deals with many genes and so, for many children they could have part of their chromosomes missing. Remember: mutations is dealing with one gene and chromosomal abnormalities are dealing with many genes. If we are talking about deletion, we are talking about the loss of a part of a chromosome.
