NATS 1760 Lecture Notes - Lecture 10: Herbicide, B Vitamins, Genetically Modified Food
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Chapter 14 : Biotechnology and Society
14.1 Origin of DNA profiles
biotech = use of recobo NA and molecular biology to prouce commodities or services.
Biotech has change the way we produce our food, diagnose and treat disease, trace our
ancestry , gather evidence for cime
14.2 Biopharming: Making Human Proteins in Animals:
before biotech, theraptueitc proteins like insulin, GH, blodd-clotting factors were isolated
from many sources, including animals in slaughterhouses, donated human blood, and
even human cadavers. Contaminated proteins from these sources exposed people to
HEMOPHILIACS cant make protein for blood clots –
Human proteins can be made in animals
Pompe disease – mutation in gene for acid-alpha glucosidase (GAA) enzyme that breaks
down glycogen to make it available as an energy source for cells.
Mutations in pompe disease eliminate or reduce enzyme levels so glucogen accumulates
in muscle cells and produces symptoms of disorder
Treatment: enzyme replacement therapy.. enzyme reduces glycogen accumulation, GAA
doses thru biotech
GAA was purified from milk of female transgenic rabbits. To increase production of
GAA is now synthesized by transgenic hamster cells gorwn in large bioreactors, marketed
TRANGENIC PLANTS replace animals hosts for making human proteins plant cells for
post translational modifications required to make human proteins fully active.
DISADVANTAGE of plant cells tho is low yields ot transgenic protein –
14.3 Stem cell treatment
Pluripotent – ability of stem cell to form any fetal or adult cell type.
Adult stem cell – stem cells revered for BONE MARROW and organ of adults. Can
differentiate to form LIMITED number of adult cells anre are multipotent – it restricted
ability of stem cell to form only one or few different cel types.
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