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Lecture 16

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Department
Natural Science
Course
NATS 1670
Professor
Motti Anafi
Semester
Fall

Description
Figure 7-24 Silent mutation CGG TAT TCG ATG AAG original sequence Arg Tyr Ser Met Lys CGC TAT TCG ATG AAG silent mutation Arg Tyr Ser Met Lys Missense Mutation Is a mutation that changes one amino acid to another A point mutation that causes a change in the amino acid sequence of the protein is a missense mutation. CGG TAT TCG ATG AAG original sequence Arg Tyr Ser Met Lys CGG TAT TTG ATG AAG missense mutation Arg Tyr Leu Met Lys Nonsense mutation A point mutation that creates a new stop codon is a nonsense mutation CGG TAT TCG ATG AAG original sequence Arg Tyr Ser Met Lys CGG TAT TCG ATT AAG Nonsense mutation Arg Tyr Ser Stop Lys Insertions and deletions http://csep10.phys.utk.edu/lightcone/Klug8E/Ch15/15_1_2a.html Frameshift Mutation CGG TAT TCG ATG AAG original sequence Arg Tyr Ser Met Lys CGG TCT TTG ATG AAG frame shift mutation (insertion) Arg Ser Phe Asp Glu • Frameshift mutation is a result of addition or deletion of one or two nucleotides (or multiple of them) o Likely to create a new triplets of nucleotides  New (useless) sequence of protein from the point of the mutation. CGG TAT TCG ATG AAG original sequence Arg Tyr Ser Met Lys Removal of A CGG TTT CGATGAAG Framshift Mutation (deletion) Ard Phe Arg Stop http://highered.mcgraw- hill.com/sites/9834092339/student_view0/chapter15/addition_and_deletion_mutations.html Consequences of Mutation • Selective advantag
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