NATS 1670 Lecture Notes - Mast Cell, Blood Plasma, Histamine

• School: York University
• Department: Natural Science
• Course: NATS 1670
• Professor: Motti Anafi

Document Summary

The inflammatory response: the inflammatory response is a coordinated set of nonspecific defenses in response to damaged cells and bacterial proteins. Inflammation is traditionally characterized by: swelling, redness, pain, heat http://www. sumanasinc. com/webcontent/animations/content/inflammatoryresponse. swf. Inflammation: histamine secreted from mast cells increases permeability of the blood vessels during inflammation. Leads to leakage of blood plasma and cells (phagocytes) to the injured site: bacteria cells lysis, phagocytes engulf and destroy bacterial cells. Neutrophils: provide the first line of defense, the main cell types seen in an inflammatory response in its initial phases, respond to chemotaxis signal from the injured site. Directed cell motion towards area with higher concentration of chemotaxis agent: neutrophils are the principal cells that engulf and ddetory the invading micro-organisms, recognition: They have surface receptors for: common bacteria cells, bacterial secreted substances http://www. garlandscience. com/garlandscience_resources/resource_detail. jsf? landing=student&resource_id=9780815341055_ch16_qtm02. Macrophages: macrophages are the other population of phagocytic cells, main activities, phagocytosis. Toxic compounds destroy the pathogen: antigen presentation for specific immunity http://www. youtube. com/watch?v=rddk0mqkz9g.