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Canada (509,645)
York University (35,302)
Natural Science (2,813)
NATS 1670 (241)
Motti Anafi (197)
Lecture

Lecture 47.docx
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Department
Natural Science
Course
NATS 1670
Professor
Motti Anafi
Semester
Fall

Description
Nevirapine: an AIDS drug Non-nucleoside Non-competitive RT inhibitors • Good blocker of mother to child transmission o Single dose before delivery to the mom and by 72 hours after delivery to the newborn reduced HIV transmission by 50% • Combination therapy with AZT o Resistance mutations are not likely to be at multiple sites • Works at very low concentrations • Minimal toxicity Protease Inhibitors Retrovirus: HIV Drug Design HIV’s protease enzyme HIV Protease Inhibitors (PI) are Substrate Analogs FDA-Approved Antiretroviral D
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