NATS 1670 Lecture Notes - Lecture 6: Live Attenuated Influenza Vaccine, Influenza A Virus Subtype H3N2, Influenza A Virus Subtype H2N2
25 Mar 2014
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Document Summary
Influenza is the single most common vaccine-preventable disease: inactivated influenza vaccine, live attenuated influenza vaccine. Year: according the infection at the other hemisphere during their current fall/winter. Igg (serum, humoral) and iga (mucosal: igg less efficient but lasts longer, antibodies to both ha and na important, antibody to ha more important (can stop virus attachment to the host cell) Inactivated split/subunit vaccines are available against influenza a and b. It elicits good humoral (igg) immunity: egg grown, 4-6month egg based manufacturing process, not for people which are allergic to eggs. 1940: the vaccine was made by using eggs. 2012: we are still using eggs, injecting the eggs with fertilizers. Live vaccine development: produced by artificial reassortment gene technology (type c with type a vaccine type, cannot take place in nature, attenuated viruses express ha and na antigens of the predicted influenza subtypes. Persons who should be vaccinated with inactivated influenza vaccine but not with live.
