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NATS 1670 (241)
Lecture

Lecture Notes

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Department
Natural Science
Course
NATS 1670
Professor
Mordechay Anafi
Semester
Winter

Description
February 10 2012 HIV ENTRY INTO THE CELL y Helper T CD4 cells are major target for HIV y Gp120 bind to CD4 y However such a binding by itself is not enough for the virus to enter the cell y Chemokine receptor CCR5 is necessary coreceptors along with CD4 RECEPTOR MUTATIONS AND HIV INFECTION y CCR5 is a chemokine receptor y Play some role in the immune system y Also important for the host cell recognition by HIV y Cells with mutant CCR5 molecules con not be infected by HIV o The HIV resistance mutation disables the CCR5 receptor wo causing any disease but also reduce the ability of the virus to enter the helper T cells y 25 of the long term carriers of
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