PSYC 4080 Lecture Notes - Lecture 6: Genetic Marker, Sensory Gating, Evoked Potential
Document Summary
A marker is always a sign but a marker involves added crieteria. Key features of a valid disease marker (2: must occur at high rate; prevalence in a target population, and low in the general population, specificity of the disease marker must also be low in other populations (ex. In depression and bipolar disorder, in comparison to scz) Marker candidate that has high sensitivity stability non-invasive and practicality: continuous performance testing. A psychological term for the p50 sensory gating effect is habituation: bonds to the click should be weaker than the first but not in schizophrenia. The p300 evoked potential reflects the brain"s reaction to novelty, updating, odd ball paradigm: gating effect of the p50--> scz patients show, p300--> an evoked potential, novelty--> contingency changes, patients take longer to show the changes in tone. No marker candidate is completely successful in identifying diagnosed patients.