Lecture 11

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Medical Laboratory Science
Jenny Rhodes

MELS223 Lecture 11 15/08/13 Roles of adhesion: Extracellular pathogens 1. Colonization of host cell surfaces or artificial surfaces 2. Efficient delivery of exotoxins into the host cell Intracellular pathogens  Critical step that precedes internalization Adhesion 1. Direct binding of bacterium to host cell  P pili (uropathogenic E.coli)  Type IV Pili (Neisseria, Enteropathogenic E.coli)  Single protein adhesins (Listeria, Enteropathogenic E.coli) 2. Indirect association with host cells (bridging)  Fibronectin binding proteins (FnBPs) – Staph aureus, Strep pyrogenes P-Pili - Abbreviation for ‘pyelonephritis-associated’ pili - Expressed by Uropathogenic E. coli (UPEC) which colonize the urinary tract and infect the kidney -Mediate bacterial adherence to epithelial cells of the bladder and kidney - Responsible for ~80% of urinary tract infections PapG: Adhesin that binds to a receptor on the surface of the human cell. PapA: Major structural component of the pilus. PapC: Outer membrane protein that forms a channel that other P- pilus components are transported through. PapD: Chaperone that binds to P-Pilus components
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