Lecture 12

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Department
Medical Laboratory Science
Course
MELS223
Professor
Jenny Rhodes
Semester
Spring

Description
MELS223 Lecture 12 8/15/2013 4:06:00 PM Invasion (internalization) Three basic mechanisms 1. Interaction with host surface receptors – Listeria, Yersinia 2. Injection of bacterial effectors into host cytosol- Salmonella, Shigella 3. Active penetration into the host cell – Toxoplasma, Plasmodium Roles of invasion 1. Access to environment suitable for growth (inside cell) 2. Protection from host antibody response – surface are more prone 3. Transversal of anatomical barriers Salmonella will stay in phagosome and modify it Listeria monocytogenes exits phagosome and stays within cell cytosol even when internalizing into the next adjacent cell  Bacteria are protected from host antibody response – 1 by 1 Transversal of anatomical barriers Intestinal  liver  via blood through blood-brain-barrier, fet
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