MELS223 Lecture 18 9/5/2013 4:07:00 PM
Don’t want whole lot of cytokine flowing through your body.
Cytokines control immune responses.
Just by tweaking cytokine production in immune diseases can fix it.
Controls direction of immune response. Part of local activation –
bring in new cells.
Amplitude- activates other cells, response gets bigger and bigger
Duration – number of cytokines during immune response
determines how long the immune response will last for.
Form specific system between:
Cells of immune system – immune system and other organs too.
Pleiotropic functions= more than one effect – overlapping or
Regulation of cytokines
Need tight regulation. Must be recognized by specific receptor on cell. Higher expression of cytokine receptor = more cytokine
Measure cytokine receptor on cells – indirect way of seeing if
cytokine is there
Balance of cytokines regulate immune response
Pro-inflammatory cytokines and anti-inflammatory cytokines
Too many cytokines systemic inflammation severe sepsis
Anti-inflammatory cytokines settle everything down again.
Endogenous pyrogens – increase thermoregulatory set-point in
Up-regulate synthesis of other pro-inflammatory cytokines – positive
IL-1, IL-6 TNFalpha – local immune response feedback to liver –
helps activate compliment (acute phase protein)
Cytokines also work on your muscles
Act on other immune cells – adaptive immune system Cytokine storm – large quantities