PHAL304 Lecture Notes - Lecture 15: Nasal Spray, Human Chorionic Gonadotropin, Thrombin
4 Sep 2013
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Document Summary
Complete failure to produce sex hormones is rare, but when it happens: Modulation of gonadotropin releasing hormone (gnrh) is the optimal therapeutic strategy. Leaves the feedback mechanisms in a more natural state. Many gnrh agonists & antagonists: agonists: gonadorelin, nafarelin. Gonadorelin: effects deoend in method of administration: Gnrh synthetic, given in pulsatile fashion. Low sperm count, immobile sperm, abnormal sperm. Administration of gonadotrophins may stimulate spermatogenesis and androgen release: female: Fsh and lh release from anterior pituitary. Results in increased gnrh, fsh & lh: induces ovulation, treats infertility due to anovulation, twins or other multiple births common, also used in males. Treats low sperm count in males due to deficiency of. Nasal spray, daily from cycle day one. Injection every day until eggs are maturing, (around. If successful: at about 12 hours nuclei fuse, chromosomes exchange, cell division begins, multiple births occur in 20-30% of pregnancies.
