MELS223 Lecture Notes - Lecture 18: Acute-Phase Protein, Cell Migration, Interleukin 10
6 Sep 2013
School
Department
Course
Professor
Document Summary
Don"t want whole lot of cytokine flowing through your body. Just by tweaking cytokine production in immune diseases can fix it. Part of local activation bring in new cells. Amplitude- activates other cells, response gets bigger and bigger. Duration number of cytokines during immune response determines how long the immune response will last for. Cells of immune system immune system and other organs too. Pleiotropic functions= more than one effect overlapping or contradictory. Must be recognized by specific receptor on cell. Higher expression of cytokine receptor = more cytokine. Measure cytokine receptor on cells indirect way of seeing if cytokine is there. Too many cytokines systemic inflammation severe sepsis. Endogenous pyrogens increase thermoregulatory set-point in hypothalamus. Up-regulate synthesis of other pro-inflammatory cytokines positive feedback loop. Il-1, il-6 tnfalpha local immune response feedback to liver helps activate compliment (acute phase protein) Act on other immune cells adaptive immune system. Cytokine storm large quantities of cytokines released.
