PSYC476 Lecture : 5. Psychostimulants.docx
23 Aug 2013
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Use these recreationally these can segway into addictive! To increase energy: overall behavioural activity, sustained effort. Functionality of the cns depends on electrical excitability of neurons/synaptic transmission. How could you decrease inhibition in the brain: gaba (inhibitory neurotransmitter, sedation) decrease. Glutamate (excitatory neurotransmitter) increase glutamergic tone. Contrary to global effects of cns depressants, psychostimulants . Tend to work on certain pathways in the brain. Tend to modulate synaptic activation rather than activate or depress activation level Psychostimulants increasing psyche activity, but not globally. All come from the same thing use an enzyme to get dopa, then another enzyme to get dopamine . Synthesis: derived from tyrosine dopa dopamine. Release: vesicular loading into pre-synaptic vesicles. D1 and d5 metabotropic gs: d2-type receptors. D2, d3 and d4 metabotropic gi, g(k+) Clearance: presynaptic transporter (dat) + ent and oct, dopamine is cleared by dat, then it is broken down by monoamine oxidase. Synthesis: derived from dopamine ne epi.
