PSYC476 Lecture : 2. Neuropharmacology Intro
20 Jan 2017
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Lipophilic = lipid based (fat loving) want to be this to get through. Turn receptor on/off or just occupy the site. Try to prevent drug entry to tissue. Manage drug if it does get in (break it down and eliminate it) Important for learning how to administer drugs effectively. How much to we need to give (dose?) How long do we need to wait to. Very soluble = high bioavailability (easily gets in) Route of administration (e. g. iv injection = 100% bioavailability because it goes straight into the blood) First-pass metabolism (break down of drug before it even gets into system) Has to do with taking drugs orally (first-pass) Take drug gets to stomach, physical breakdown/enzymatic breakdown/protein- peptidases. Carries on down gi tract into intestines. Small intestine (si) = absorption (getting things broken down even further into things that can be absorbed) important part because this is where drug gets into system. Large intestine (li) = bringing water absorption.
