BIOSCI 106 Lecture Notes - Lecture 3: Anencephaly, Hydrolysis, Transferase
4 Sep 2013
School
Department
Course
Professor
Document Summary
Complex structure made of glutamic acid, p-aminobenzonic acid and pteridine derivative. Sources include liver, spinach, citrus, fresh vegetables, not found in animal products such as milk, meat and eggs. You can get some folate from intestinal bacteria. Daily requirement is about 100-200 micrograms or 400+ micrograms is pregnant or undergoing/undergone trauma. A structural component of purines, pyrimidines and the nucleotides derived from them. Folate levels are usually okay in a normal diet though poor dietary habits can lead to folate deficiency eg alcoholism. Folate deficiency in non alcoholics can be due to impaired absorption or metabolism or increased need for the vitamin eg pregnancy. Causes anaemia in various forms, both white and red blood cells are affected because of the failure to synthesis dna when the blood cells are created. Anaemia in megablastic and macrocytic form, as there is no dna synthesis results in large rbc with many nuclei due to no division.
