BIO-1801 Lecture Notes - Lecture 26: Lysosome, Color Blindness, Meiosis

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26 Apr 2017
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Clicker Question: Mendels law of segregation states:
Alleles on homologous chromosomes seperate during meiosis (during gamete formation)
Multiple Alleles
3 or more alleles for a given trait
X-linked inheritance
X^H Y x X^H X^h
XHXH
XHY
XHXh
XhY
males are more susceptible to genetic disorders
pedigree anaylisis
looking at one generation after the next, follow the alleles and the traits using
squares and circles (males are square)
express the trait, solid
carrier only half if filled
Color blindness
C= normal
c=color blind
Clicker Question: A color blind mom and a normal vision man cannot have:
XCY x XcXc
cannot have a son with normal vision
Autosomal Recessive disorder
can use pedigree
albinism is caused by a recessive allele, not sex linked
Cystic fibrosis
genetic disorder where body mucous is not produced correctly
a faulty gene
Product rule
provide critical information
ex. cystic fibrosis both parents are carriers
if one kid, 25% chance 1 kid
if two kids with cystic fibrosis, 6.3% chance
three kids, 0.25 x 0.25 x 0.25 = 1.6%
ex. one parent carries, other parents has it
one kid 50% chance
two kids 25% chance
3 kids 12.5% chance
Tay -sachs
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