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BIO 2400 (24)
Lecture 11

BIO 2400 Lecture 11: Ch. 11

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BIO 2400
Annkatrin Rose

Ch. 11 • DNA Replication o Copying the genetic material ▪ Original DNA strands, templates (parental) for the synthesis of new DNA o During S-phase of cell cycle o Very quick and accurate • Meselson and Stahl Experiment o Distinguish parent and daughter strands ▪ 14N (light isotope) and 15N (heavy isotope of N) o After one generation, DNA is “half-heavy” o Consistent with semi-conservative model of DNA replication  What expected result if the Meselson and Stahl experiment were carried out for four generations? 7/8 light; 1/8 half heavy  What expected result if the Meselson and Stahl experiment were carried out for five generations? 15/16 light, 1/16 half heavy  What would be the expected result of the Meselson and Stahl experiment after three generations if DNA replication was dispersive? All 1/8 heavy • Initiation o Requires origin of replication ▪ Easy to unwind dub strand ▪ Prokaryotes= single origin o Replicon- individual unit of replication ▪ Prokaryotes—entire bacterial chromosome ▪ Eukaryotes—20,000-300,000 bp o Prokaryotic Replication Iniation ▪ DNA involved- oriC region ▪ Proteins i
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