BIO-2600 Lecture Notes - Lecture 2: Lamin, Cathepsin, Protein Targeting
22 Feb 2018
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Document Summary
Eukaryotic cells have devised a strategy to efficiently subdivide potentially incompatible biochemical processes as discrete compartments (organelles) The unique functions of different organelles are based on the activities of resident proteins that must be precisely sorted and targeted to their proper destinations in the cell (protein sorting) A communication system exists whereby small membrane bound vesicles shuttle materials to and from different organelles and the cell surface (vesicle trafficking) Placing a protein in the lysosome involves its synthesis at ribosomes followed by its transit through several intermediary cellular compartments including the er, golgi, and endosomes. Transit to the lysosome overlaps with pathways to other cellular destinations. An excellent example of the three part requirement for protein sorting can be seen for proteins that reside in the nucleus (e. g nuclear lamins) The nuclear lamina is a dense network of cytoskeletal proteins that cage the interior of the nucleus protecting its contents, the dna.
