CHE-2201 Lecture Notes - Lecture 7: Nucleophile, Sulfonate, Nucleophilic Substitution
Document Summary
One group of atoms is replaced with another. The weaker the base, the better the leaving group. As you go down the halogens, the stronger the acids become. I- is a weak conjugate base, so it will be a good leaving group. Fluorine is not a very good leaving group. During substitution, one group attacks and one group leaves. Good leaving groups must fulfill two criteria to encourage substitution: The electronegative leaving group creates a partial charge on the site of attack to attract the negative charge of the nucleophile. The leaving group must be able to stabilize the electrons it leaves with. Alkyl halides are compounds where a carbon group (alkyl) is bonded to a halide (f, The halide group is the key substituent we will name and locate. There are three types of alkyl hydrides (diagram) Structure determines function it determines how it can react with other molecules.
