BIO 3422 Lecture Notes - Lecture 5: External Intercostal Muscles, Internal Intercostal Muscles, Pulmonary Pleurae

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16 Dec 2017
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Conducting zone/dead space: moves air in and out: larynx, voicebox, trachea, bronchi, bronchioles, mucus secretory cell- ciliated, propels towards pharynx (provide warm and moisturize air) Respiratory zone: alveoli sacs, gas exchange: type 1 alveolar cell: gas exchange, thin wall. Respiratory membrane: type 2 alveolar cell: produce surfactant. Surfactant/surface tension: surface tension causes lungs to collapse, surfactant breaks the tension making it easier for the lungs to change volume (more compliant) Intrapleural space/pleural fluid: pressure = -4mmhg, vacuum, reduce friction. Somatic motor neurons in skeletal muscles (diaphragm and external intercostal muscles contract/expand, increase volume decrease pressure. Passive: relaxation of diaphragm and external intercostal muscles, decrease volume, increase pressure, palv=+1>patm. Lung compliance: high compliance = less work (easier to fill lungs with air) Respiratory distress- newborns no surfactant = harder to move, requires more energy. Airway resistance (increase resistance = increase work = increase pressure gradient) Asthma- bronchoconstriction: inhaler (b2 agonist causes bronchodilation. Minute ventilation= tidal volume x breathing rate.

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