NSC 3319 Lecture Notes - Lecture 30: Twin Study, Emic And Etic, Neuroanatomy
10 May 2016
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Schizophrenia ( nestler 16: what is schizophrenia. Is a disorder that affects every aspect of function. Ideas of reference: very paranoid, schizo ppl do but normal ppl don t. Negative: the behavioral deficit, social withdrawal, loss of motivation/ interest, loss of pleasure. Prodromal stage: before diagnosis, social withdrawal is usually the first symptoms, causes, genetic. Genes may confer risks: disci, the n one is very important in the formation of synapses during brain development. But finding them is very difficult b/c it is probably a pleotropic disorders: many genes have a small contribution to the disorder. It had been very difficult to discover which genes have the most affect. All the behavioral genetics suggest that it as a genetic component- twin studies: anatomical. Loss of grey matter all over: most in the pfc and hippocampus, but its not cell body loss rather it is synapse or neuropil, meaning that there is something wrong in synaptic organization.
