BIOL3030 Lecture Notes - Lecture 17: Sickle-Cell Disease, Thromboxane A2, Vascular Smooth Muscle
4 Apr 2017
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Energy metabolism i: measuring metabolic rate: factors influencing vo2. Indirect measure of how much energy is produced. Over course of animal life: produce different hemoglobin. Fetal hbg in utero, after birth: adult/maternal hemoglobin. Rbc count fluctuations: contains/produce hemoglobin: intracellular pigment. Way to adjust oxygen carrying capacity: hemaetopoesis. Erythropoetin stimulates red bone marrow to increase rbc count. Add to o2 carrying capacity of blood. Stimulus: hypoxia due to decreased rbc count, decreased availability of o2 to blood, increase tissue demands for o2. Too much rbc: would start to clot bc too thick/viscous. Dark muscle: more hem: bound to myoglobin and mitochondria. Darker muscles: more mito and more myoglobin. Dark and light meat in chicken: more for energy production than power. More blood rich in heem bc of myoblogin. Heeder organ: produce a lot of energy in tuna. Normal enzymatic, asymptotic reaction curve for enzyme. Sharp increase with substrate, then tail off when. Not bound to 3 other units like hemoglobin.
