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Lecture

Genome Replication.docx

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Department
Biology
Course
BIOL 3150
Professor
Cam
Semester
Fall

Description
Genome Replication (Chapter 15) • Double helix model proposed by Watson and Crick permitted for three modes for DNAReplication: Dispersive, Semiconservative and Conservative • Heavy isotope labeling experiment by Meselson and Stahl supported DNAreplication via semiconservative mechanism • DNAdouble helix suggests topological problem w/ DNAreplication: torsional stress stored by undergoing supercoiling, unwinding creates more stress • Cells contain topoisomerases – enzymes that can regulate various levels of DNA supercoiling (Type I and II) unwinding ahead of replication fork allow for DNA polymerase to proceed without rotating helix • DNAreplication begins at origin of replication, one in bacteria, many in eukaryotes o OriC in E.coli recognized by DnaAproteins and melted • All DNApolymerases require a template with a free 3’OH to catalyze DNAsynthesis,
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