BIOL 3210 Lecture Notes - Lecture 23: Myoglobin, Ctla-4, Alpha Helix
Document Summary
Protein with a bound heme group (irreversibly bound prosthetic) Cooperativity why it can bind efficiently in some areas. The iron is in the ferrous (2+) state, and can only bind to oxygen: this iron has 6 potential bonds it can form, 4 of them are tied up with nitrogen, 2 are available. So one of the 2 bind oxygen, and the other interacts with a histidine in the globin. When ferrous heme is not bound to oxygen, it is blue violet, when it is, it is red. When its oxidized to ferric (3+) it is brown: that"s why fresh meat is red, older meat is brown. The alpha helices are depicted like the cylinders, and are all named by letters. Binding at a lower partial pressure than hemoglobin. Fractional saturation indicated the proportion of the oxygen carrier that is bound by oxygen. The higher the ka is, the higher the affinity. Don"t need to memorize this, but a reminder.
