BIOL 4330 Lecture Notes - Lecture 10: Skeletal Muscle, Pacemaker Potential, Sarcomere
16 Mar 2018
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Document Summary
Cell types in the heart: cardiomyocytes, contractile, analagous to skeletal muscle. Interacts with both myosin: green m-cadherin, adhesion molecule in intercalated discs, blue nuclei of each cell, going to form 30-40 % of the heart, branched, only 1 nuclei per cell normally, similarities to skeletal muscle, proteins. Lecture 10: spiral configuration, to allow ventricular contraction that is in a wringing motion, unlike skeletal muscle, which is straight. Overall structural components of the heart: myocardium, contractile cells that are covered with very thin epithelial layer and a little bit of connective tissue, endocardium. Inflammation of endocarditis: due to bacterial infection, mostly caused by strep, leads to problems with contraction, pericarditis. Inflammation due to bacteria or virus: fluid buildup between layers, puts pressure on the heart, reduces cardiac output. Good study guide to compare and contrast skeletal muscle and basics of cardiac muscle contraction. Overview: structural organization of myocardial cells (differ from skm, very sparse sarcoplasmic reticulum, very sparse sarcoplasmic reticulum.
