BIOL 4330 Lecture Notes - Lecture 19: Pulmonary Artery, Vital Capacity, Respiratory Sounds

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Pulmonary arterioles respond weakly to changes in carbon dioxide pressure. Bronchioles are more sensitive to carbon dioxide. Pulmonary arterioles are how they differ from systemic (exactly opposite) Lecture 19: degree of tenacity, alpha and beta are both expressed constitutively when talking about pulmonary arteries, bias towards beta. Inability to exchange gas efficiently is going to be considered respiratory failure. Blood: only fluid tissue in the body. Hemoglobin critical protein involved in gas transport: all hemoglobin in body is going to be synthesized before leaves bone marrow, 10^6 per red blood cell, gene expression in rbc is tightly controlled. Iron dictates hemoglobin production: heterotetramer, each can bind 1 oxygen molecule, oxygen binding to hemoglobin is cooperative binding, enables it to deliver 1. 7x as much oxygen than if it were not cooperative. Inside a rbc it will be protected from break down. Importance and involvement at the pulmonary and systemic capillaries: will ultimately be able to drive gas exchange.

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