BIOL 4330 Lecture Notes - Lecture 20: Pulmonary Edema, Chronic Obstructive Pulmonary Disease, Perfusion
Document Summary
Lecture 20: air gets into alveoli before it gets transported into the blood. Carbon dioxide unloading: gas in alveoli, around 40mmhg, gas in carbon dioxide rich blood is 46mmhg, diffuse from blood into alveoli until equilibrium is reached, highly soluble co2, 20x more than oxygen requires less steep gradient. Hypoxia: too little oxygen is reaching the blood, o(cid:454)(cid:455)gen itself isn"t a(cid:272)ti(cid:448)el(cid:455) diffusing, co poisoning, co competitively binds with hemoglobin, 200x more affinity to hemoglobin binding sites than oxygen. Increased diffusion distance: excess fluid between alveolar space and capillary pulmonary edema, fluid balance at the capillary, more in other system next week, affects tissue oxygenation, affects rbcs, bleeding, anemia, influences hemoglobin. Inefficient gas exchange because it increases distance between capillary and alveoli: e(cid:448)en ha(cid:396)de(cid:396) (cid:271)e(cid:272)ause o(cid:454)(cid:455)gen (cid:272)an"t get th(cid:396)ough li(cid:395)uid easil(cid:455, compliance decreased, asthma. Impacting thickness of endothelial wall or membrane: decreases ability to diffuse, all of these are going to impact gas exchange.
