BIO ENG 10 Lecture Notes - Lecture 6: Diabetic Foot Ulcer, Hematopoietic Stem Cell Transplantation, Diabetic Foot
Document Summary
Problem: diabetic foot ulcers - causes nerve damage, lack of blood flow. 15% of patients with diabetes form foot ulcers; 80% of lower leg amputations are preceded by a diabetic foot ulcer. Artificial implants: long-term wear, different rejection issues, limited control over structure and function. Tissue engineering: create new tissue or an implant that will develop into new tissue. History - blood transfusion -> bone marrow transplant -> carticel -> dermagraft. Let the body do the work to grow organs instead of creating them outside the body. We might want cells to differentiate, migrate, proliferate, form structures, or make proteins. Adult stem cells - in stem cell form, or differentiate them in culture. Extracellular matrix (ecm): structural material that binds us together. Provides structural/mechanical support for cells/body, made up of a large number of components (mostly protein) Regulate food, biologics, drugs, medical devices, animal and veterinary, cosmetics, radiation-emitting products.