INTEGBI 35AC Lecture Notes - Hemoglobin, Allele Frequency, Protozoa
23 Oct 2013
School
Department
Course
Professor
Document Summary
Heart disease is the biggest causes of death. Founder: person with mutaton that gets passed down: ex: hereditary hemochromatosis. Hfe gene c282y, same mutation from about 800 years ago (celtic viking decent) Body is too good at absorbing iron. How to determine how long ago was the founder use chromosomes: small region = long ago, long region = more recent. Sickle cell anemia classic simple example: deals with red blood cells hemoglobin (transports oxygen, anemia reduces red blood cells or screws up hemoglobin, donut sickle shape. Can"t function as well, can"t produce enough. Don"t transport oxygen well enough tissue death. Death in infancy: point/missense mutation abnormal hemoglobin. Inheritance of sickle: autosomal recessive, hba dominant vs hbs recessive, only homozygous are screwed over. Linus pauling: suggested problem with hemoglobin. 1/12 african americans have sickle cell trait/heterozygotes: stress brings out symptoms. Ex: athletes: more common in certain areas of the map than others.
