MCELLBI 55 Lecture Notes - Lecture 13: Damselfly, Herd Immunity, Macrophage
23 Jan 2018
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Document Summary
Poliomyelitis (polio) poliovirus ssrna virus in picornavirus family of viruses. Pentamers form icosahedral structure with rna inside. More stable without envelope outside of cell simple virus with only 12-17 proteins transmission fecal/oral transmission contaminated water or hand/mouth contact called an enterovirus because it infects the gastrointestinal tract infection/disease. Virus replicates in gi tract cells and then is shed in feces to next host. 24% can develop fever, headache, and/or sore throat. Only 1 in 150 have neurological infection. Virus spreads from gi tract to system to cause symptoms and can infect neurons (especially motor neurons) paralysis. Virus can infect neurons that control breathing. Patients need to be in iron lung pathogen success. Only found in humans but able to infect up to 100% of humans. Cases were rare but started increasing in many countries started recognizing seasonality. Poliovirus seasonal with warm weather and/or humidity countries with improved sanitation and clean water had highest rates of paralysis from polio.
