MCELLBI C64 Lecture Notes - Lecture 1: Premotor Cortex, Supplementary Motor Area, Antibody
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22 Dec 2016
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A muscle fiber is the name of a single muscle cell. Skeletal muscle fibers were formed by the fusion of several cells in development, so they have several nuclei. Each muscle contains lots of muscle fibers. A single motor unit consists of a motor neuron and all of the muscle fibers it controls. Stimulation of the muscles adds up to a sustained contraction. The neuromuscular junction and excitation contraction coupling. The neuromuscular junction is the point of synaptic contact between the axon terminal of a motor neuron and the muscle fiber it controls. Action potentials in the motor neuron cause acetylcholine release into the neuromuscular junction. Muscle contraction follows the delivery of acetylcholine to the muscle fiber. Action potentials on muscle cells (=fibers) cause contraction by releasing ca ions from intracellular stores. Acetylcholine is released at the neuromuscular junctions. The nt binds the receptors, which depolarizes the muscle cell. This allows the sarcoplasmic reticulum to release calcium.
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