MCELLBI C64 Lecture Notes - Lecture 2: Deep Brain Stimulation, Globus Pallidus, Substantia Nigra
22 Dec 2016
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Document Summary
More about the structures of the basal ganglia. When you want to move, brain needs to quiet it so signals can go through thalamus. In all the systems the neurons that are involved are inhibitory, the output of those areas are inhibitory, release gaba, quiet down. Stubstantia nigra pars reticula (involved in eye movement) Stubstantia nigra pars compata (damage to area causes parkinson"s) Not releasing gaba is subthalamic nucleus, excitatory & substantia nigra pars compata which releases dopamine. Dopamine is excitatory or inhibitory depending on receptors in post synaptic cell. Know the picture, label structures, and what neurotransmitters are released. Thalamus - not part of basal ganglia but regulated by it. Neurons in this area are mostly active even if we don"t give them a signal. Globus pallidus internal is constantly inhibiting the thalamus which prevents it from being able to act (if inhibited, cant move)
