PB HLTH 162A Lecture Notes - Lecture 11: Plasmodium Falciparum, Trypanosoma Brucei, Adaptive Immune System
30 Dec 2019
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Etiologic diagnosis: (detection does not = diagnosis; could have asymptomatic or undiagnosed cases) etiology: identification of disease in terms of its cause (identify microorganism/ etiological agent; ie- myco. falciparum in lab) To treat & control disease (& respond to epidemics) Knowing organism or molecular level (specific strain) To report to state health department (tracking reportable disease s- levels, location, outbreaks, etc. ) Lab diagnosis (depending on stage of disease, use different method; detect pathogen using innate or adaptive immune response, type of antibody depends on time since infection/stage of disease, ie- igm > igg) Ie- identify dif stages of plasmodium falciparum (malaria) in rbcs, trypanosoma brucei among rbcs. Rapid antigen test (detect protein on pathogen using antibodies ) Strip w/band that changes color (ie- when encounter antigen on influenza) Latex agglutination test w/bacteria (b cell antibodies form lattice when they encounter antigen) Molecular/pcr (look for nucleic acid of pathogen)
