BIOLOGY 174 Lecture Notes - Lecture 19: Bohr Effect, Hemoglobin, Reversible Reaction
17 Mar 2017
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100 ml of blood contains 20 ml of oxygen. 98. 5% bound to hemoglobin inside rbc hemoglobin + oxygen = oxyhemoglobin (dark purple in color) ( red) Reversible reaction adding oxygen = loading subtracting oxygen = unloading. The influence of po2 on hemoglobin saturation (the percentage of hemoglobin that has oxygen bound) Graph: the oxygen hemoglobin dissociation curve or (o2-hb saturation curve) Lungs po2 100 - nearly all of hemoglobin is loaded 99% oxyhemoglobin. Tissues po2 40 75% of hemoglobin is loaded. 25% represents oxygen that was unloaded from hemoglobin for use by tissues. Factors that shift the oxygen-hemoglobin dissociation curve to the right: 100% saturated in lungs: decreased ph (increased h+) (acidic) (bohr effect) More oxygen is unloaded at given po2, allows for more oxygen to be delivered to the exercising muscles. Increased 2,3-bisphosphoglycerate (bpg: compound inside red blood cells that increases oxygen unloading for use by tissues.
