CAS AN 263 Lecture Notes - Lecture 7: Underarm Hair, Adrenal Gland, Adrenarche
9 Feb 2018
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Document Summary
Females: breast development, pubic hair, growth spurt, hip broadening, menstruation, fat deposition, fully fecund cycles. Development of lh pulses: pre-puberty: no lh pulses, early puberty: production of lh pulses begins, especially at night, late puberty: increasing magnitude and frequency of pulses, also during day. Estradiol phase ii: eventually stimulates mineral deposition resulting in ossification and fusion of growth plates (fused plates stop growth) Overall skeletal development involves: (1) androgens (testosterone) (2) estradiol (3) growth hormone from anterior pituitary. Secular trend: 1840: average age at menarche was 17 years in european populations, now: average age at menarche is 13 years in european populations, factors affecting this trend include: nutrition, hygiene, and immunity. Precocious puberty: young girls (~ ages 4-5) who went through puberty very early are treated with estrogen antagonist. Delayed or loss of puberty: older girls (~age 20) who have delayed or loss of puberty are treated with gnrh.
