CAS BI 203 Lecture Notes - Lecture 16: Golgi Apparatus, Heterochromatin, Bromodeoxyuridine

• School: Boston University
• Department: Biology
• Course: CAS BI 203
• Professor: Francis Monette

Document Summary

The nucleus: structure of the nuclear envelope, inner & outer membranes (double membrane surrounds the nucleus) Made up of two phospholipid bilayers and lumen ( perinuclear space ) The perinuclear space is continuous with the lumen of the er. Ribosomes are attached to the er: why, help with translation of molecules for the secretory pathway. Nuclear lamina structurally supports the nuclear envelope"s membrane: nuclear lamina (structural organization beneath the nuclear membrane) Gives the nucleus" membrane some shape and rigidity. Primary component = lamins ( fibrous proteins: lamins are a type of intermediate filament protein, most intermediate filament proteins can form more complex structures (like lamins) A lamin polypeptide with first coil around itself to form a dimer and then is able to form head-to-tail associations of dimers. Eventually, the head-to-tail associations of dimers can form higher order structures that can associate side-by-side leads to a mesh-like structure under the nuclear membrane. Mutations in lamin genes cause several inherited tissue-specific diseases.