CAS BI 203 Lecture Notes - Lecture 7: Ribosome-Binding Site, Cpg Site, Methyl Group
7 Feb 2014
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I"d like to resume the conversation on gene. It"s not changing the base sequence c, a, g, and t. 3183 [00:00:18. 56] but what can happen is you can methylate, you can add a methyl group to. And we"ll see methyl c on the next slide. But for now, we"ll just note that in particular, 3185 these enzymes like methylate the c bases when they occur in a cg island. 3186 cpg island, which is inferring that it"s a 5" to 3" direction, so when c precedes g. 3187 [00:00:49. 04] and you have some cg clusters in promoter regions. 3188 methylated, different types of gene regulation will occur. 3189 turned off if their promoters are methylated. 3190 [00:01:08. 35] but i"ll say as an aside, methylation can also turn on some other promoters. 3191 general case is that it"s going to turn things off. 3192 had a protein repressing this gene, now you"ve got covalent additions to the dna itself that"s.
