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Lecture 4

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Department
Biology
Course
CAS BI 315
Professor
Eric Widmaier
Semester
Spring

Description
Lecture 4 02/16/2014 Typical body of intracellular fluid 300 mOsm  Only need a change of ~1% to trigger a “thrist” sensation­also triggers homeostatic reflexes that would  absorb that water rather than releasing it to the kidneys.  150 mM = 300mOsm Tight junctions allow water to pass (Figure 4.24)  Epithelial cells can segregate it’s proteins relative to different membranes. Creates an imbalance­sodium is concentrated in the interstitial fluid▯creates an osmotic gradient. Water will only move if you create a way for it to move. Intracellular fluid is very different from the  extracellular compartment. Energy is expended to create an imbalance: gradients are crucial; cardiac cells secondary transport.; it also  creates a charge imbalance because the ions are charged.  Figure 4.6; charges line up along the membrane; the net flux of a charge is a current. Volts measures the  potential of a current across a membrane; measures the difference of charge across 2 things: inside the cell  relative to the outside.  70 mV­charge difference inside with respect t
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